Antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea by CUPRAC and FRAP methods

Authors

  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Rifda Amaliya Ma’ruf Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Syukur Berkat Waruwu Faculty of Pharmacy and Health Sciences, Universitas Sari Mutiara Indonesia, Medan, 20123, Indonesia
  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Hari Purnomo4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281 Indonesia

DOI:

https://doi.org/10.32734/idjpcr.v6i1.17768

Keywords:

Antioxidant, Free radicals, Inflammation, p-aminophenol, 1.3-bis(p-hydroxyphenyl)urea

Abstract

An imbalance in the number of free radicals produced in the body can result in oxidative stress. Excessive oxidative stress can lead to chronic inflammation, which in turn can lead to most chronic diseases. Inflammation is related to oxidation through increased reactive oxidative stress, which can target modulators associated with inflammation, such as inflammatory cytokines. Antioxidants can inhibit or stop oxidation by protecting the body and neutralizing free radicals. 1.3-bis(p-hydroxyphenyl)urea is a modification of p-aminophenol and has hepatotoxic side effects such as those caused by acetaminophen. This compound can relieve pain, is anti-inflammatory, and has fewer side effects. This research was conducted to evaluate the antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method and the FRAP (Ferric Reducing Antioxidant Power) method. The results of the CUPRAC method research show that the 1.3-bis(p-hydroxyphenyl)urea compound has an IC50 value of 4.40 ± 0.07 μg/mL. Meanwhile, the FRAP method was 29.36 ± 1.20 μg/mL. Apart from suppressing inflammation, this compound has the potential to be an antioxidant compound.

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Published

2023-04-30

How to Cite

Satria, D., Rifda Amaliya Ma’ruf, Syukur Berkat Waruwu, Urip Harahap, & Hari Purnomo4. (2023). Antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea by CUPRAC and FRAP methods. Indonesian Journal of Pharmaceutical and Clinical Research, 6(1), 48–54. https://doi.org/10.32734/idjpcr.v6i1.17768

Issue

Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research

Section

Articles

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