Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

Authors

  • Alfi Dewi Sholat Universitas Sumatera Utara
  • Dairion Gatot Universitas Sumatera Utara
  • Savina Handayani Universitas Sumatera Utara
  • Andri Iskandar Mardia Universitas Sumatera Utara
  • Santi Syafril Universitas Sumatera Utara

DOI:

https://doi.org/10.32734/sumej.v1i1.439

Abstract

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

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Published

2018-10-01

How to Cite

1.
Sholat AD, Gatot D, Handayani S, Mardia AI, Syafril S. Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer. Sumat. Med. J. [Internet]. 2018Oct.1 [cited 2025Aug.5];1(1):1-5. Available from: https://idjpcr.usu.ac.id/smj/article/view/439

Issue

Vol. 1 No. 1 (2018): Sumatera Medical Journal (SUMEJ)

Section

Research Article

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